Dra. Mancilla Percino Teresa

Dra. Teresa Mancilla Percino

Doctorado:
Doctora en Ciencias en la especialidad de Química Orgánica, Centro de Investigación y de Estudios Avanzados del I. P. N., México, 1985


Tel: +52 55 5747-3396
tmancill@cinvestav.mx

 

Líneas de investigación

Diseño, síntesis, caracterización estructural de compuestos polifuncionales de interés biológico como: moléculas orgánicas derivados de aminoalcoholes, aminoésteres, aminoácidos, hidroxiamidas, amidas, aminas, ácido iminodiacético y aminodiésteres; heterociclos de boro y de compuestos organoestaño (IV) derivados de las moléculas orgánicas. Caracterización y análisis estructural de compuestos polifuncionales por RMN de 1H, 11B, 13C, 19F, 15N, y 119Sn, así como por las técnicas de RMN, difracción de rayos-X, infrarrojo, espectrometría de masas y análisis elemental.

Evaluación biológica de compuestos polifuncionales como antiinflamatorios, moduladores de canales de calcio y antitumorales a través del modelado molecular e in vitro para investigar la selectividad de ellas como inhibidoras de las enzimas COX-1 y COX-2, Lipoxigenasa, bloqueadores de canales de calcio, actividad inhibitoria sobre la HDAC8 y actividad antiproliferativa sobre las líneas celulares tumorales HeLa, U373 y MDA-MB-231 entre otras.  

Maryam Taherzadeh, Mehrdad Pourayoubi, Banafsheh Vahdani Alviri, Samad Shoghpour Bayraq, Maral Ariani, Marek Necas, Michal Dušek, Václav Eigner, Hadi Amiri Rudbari, Giuseppe Bruno, Teresa Mancilla Percino, Marco A. Leyva-Ramírez and Krishnan Damodaran. Hydrogen-bond directionality and symmetry in [C(O)NH](N)2P(O)-based structures: a comparison between X-ray crystallography data and neutron-normalized values, and evaluation of reliability. Acta Cryst. B77, 2021, 384–396

Flor Paulina Garrido González, Teresa Mancilla Percino. Synthesis, docking study and inhibitory activity of 2,6-diketopiperazines derived from a-amino acids on HDAC8, Bioorganic Chemistry 102, 2020, 104080, 1-10.

Juan A. M. De la Rosa, Maricela García-Castañeda, Takuya Nishigaki, Juan Carlos Gómora, Teresa Mancilla-Percino, and Guillermo Ávila. Interaction of MDIMP with the Voltage-Gated Calcium Channels. Molecular Pharmacology 98 (3), 2020, 211-221.

Teresa Mancilla Percino, José Eduardo Guzmán Ramirez, Elvia Mera Jiménez and Cynthia Raquel Trejo Muñoz. Synthesis, characterization of novel isoindolinyl- and bis-isoindolinyl phenyl boronic anhydrides. Antiproliferative activity on glioblastoma cells and microglial cells assays of boron and isoindolines compounds. Journal of Organometallic Chemistry 891, 2019, 35-43.

Genaro Rodríguez-Uribe, Nicolas Serafín-Higuera, Gabriela Damian Morales, Enoc Mariano Cortés-Malagón, Vicky García-Hernández, Odette Verdejo-Torres, Jessica Paulina Campos-Blázquez, Cynthia R. Trejo-Muñoz, Rubén Gerardo Contreras, Rodolfo Ocadiz-Delgado, Carmen Palacios-Reyes, Paul F. Lambert, Anne E. Griep, Teresa Mancilla-Percino, Jaime Escobar-Herrera, Elizabeth Álvarez- Ríos, Carlos Ugarte-Briones, José Moreno, Patricio Gariglio and José Bonilla-Delgado. HPV16-E6 Oncoprotein Activates TGF-𝛽 and Wnt/𝛽-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model. BioMed Research International, Volume 2018, Article ID 2847873, 1-17.

Mireille Aline Santamaria-Herrera, Erick Benjamín Ríos-Pérez, Juan Antonio Manuel de la Rosa, Maricela García-Castañeda, Diana Stephanie Osornio-Garduño, Roberto Ramos-Mondragón, Teresa Mancilla-Percino, Guillermo Ávila. MDIMP, a novel cardiac Ca2+ channel blocker with atrial selectivity. European Journal of Pharmacology 781, 2016, 218–228. 

Teresa Mancilla-Percino, Cynthia R. Trejo-Muñoz, José Alfredo Díaz- Gandarilla, Patricia Talamás-Rohana, José Eduardo Guzmán Ramírez, Jair Cervantes C and Armando Figueroa Ortiz. Isoindoline Derivatives of a-Amino Acids as Cyclooxygenase 1 and 2 Inhibitors. Arch. Pharm. Chem. Life Sci., 349 (3), 2016, 175-185.

Hassan Hosseini-Monfared, Rahman Bikas, Sakine Mohammadi, Teresa Mancilla Percino, Serhiy Demeshko, Franc Meyer, Marco A. Leyva Ramírez. Synthesis, Structure, Magnetic Properties, and Catalase-like Activity of Methoxy-bridged Manganese (III) Coordination Polymer containing Hydrazone based (O,N,O)2-Donor Ligand. Z. Anorg. Allg. Chem. 640, 2014, 405–411.

Cynthia R. Trejo Muñoz, Elvia Mera Jiménez, Rodolfo Pinto-Almazán, José Alfredo Díaz Gandarilla, José Correa-Basurto, José G. Trujillo-Ferrara, Christian Guerra-Araiza, Patricia Talamás Rohana, Teresa Mancilla Percino. Effect of two series of isoindolines over HDAC8 activity and expression. Medicinal Chemical Research, 23, 2014, 3227–3234.

Mehrdad Pourayoubi, Atekeh Tarahhomi, James A. Golen, Poorya Zargaran, Behrouz Elahi, Arnold L. Rheingold, Marco A. Leyva Ramírez, Teresa Mancilla Percino. Hirshfeld surface analysis of new phosphoramidates. Acta Crystallographica Section B, B69 (3), (2013), 260-270.

Mehrdad Pourayoubi, Maryam Toghraee, Vladimir Divjakovic, Arie van der Lee, Teresa Mancilla Percino, Marco A. Leyva Ramírez, Anahid Saneei. Analysis of N—H· · ·O hydrogen bonds in new C(O)—NH—P(O)-based phosphoric triamides and analogous structures deposited in the Cambridge Structural Database. Acta Crystallographica Section B B69, (2013), 184-194.

Cynthia R. Trejo Muñoz, Teresa Mancilla Percino, Elvia Mera Jiménez, José Correa-Basurto and José G. Trujillo Ferrara. Partition coefficient determination of a series of isoindolines-2-substituted and its correlation with their antiproliferative activity on HeLa cells. Medicinal Chemical Research, 22 (8), (2013), 4039-4045.

Feliciano Tamay-Cach, José Correa-Basurto, Lourdes Villa-Tanaca, Teresa Mancilla-Percino, Margarita Juárez-Montiel and José G. Trujillo-Ferrara. Evaluation of new antimicrobial agents on Bacillus spp. strains:  docking affinity and in vitro inhibition of glutamate-racemase. Journal of Enzyme Inhibition and Medicinal Chemistry, 28 (5), 2013, 1026-1033.

J. Correa-Basurto, F. R. Ramos-Morales, M. H. Matus, M. C. Rosales-Hernández, T. Mancilla-Percino, J. Trujillo-Ferrara and I. Ilizaliturri-Flores. Docking and DFT Studies to explore the Topoisomerase II ATP Pocket employing 3-Substituted 2,6-Piperazindiones for drug design. Molecular Simulation 38 (13), 2012, 1072-1084.

M. A. Soriano-Ursúa, T. Mancilla-Percino, J. Correa-Basurto, E.  Querejeta and J. G. Trujillo-Ferrara. Give Boron a chance: Boron containing compounds reach ionotropic and metabotropic transmembrane receptor. Mini-Reviews in Medicinal Chemistry 11 (12), 2011, 1031-1038.

Zohreh Shoberi, Mehrdad Pourayoubi, Akbar Heydari, Teresa Mancilla Percino, Marco A. Leyva Ramírez. Ultrasound assisted synthesis of Cs2.5H0.5PW12O40: An efficient nano-catalyst for preparation of ß-amino ketones via aza-Michael addition reactions. Comptes Rendus Chimie 14 (6), 2011, 597-603.

Mehrdad Pourayoubi, Hossein Eshtiagh-Hosseini, Somayyeh Sanaei Ataabadi, Teresa Mancilla Percino and Marco A. Leyva Ramírez. 9-Aminoacridinium nitrate monohydrate. Acta Crysallographica Section E E67 (3), 2011, o565.

M. E. Acosta-Hernández, T. Mancilla-Percino, J. Correa-Basurto, M. Saavedra Vélez, F. R. Ramos Morales, Jesús S. Cruz-Sánchez, S. Duran Niconoff. Depression in children and adolescents: a mental disorder of our times. Arch. Neurocien (Mex) 16 (1), 2011, 19-24.

Mehrdad Pourayoubi, Mahnaz Rostami Chaijan, Teresa Mancilla Percino and Marco A. Leyva Ramírez. Crystal Structure of dichlorobis(4-amino-1,2,4-triazole)dimethyltin(IV), SnCl2 (CH3)2 (C2H4N4)2. Z. Kristallogr. NCS 226 (1), 2011, 115-116.Fahimeh Sabbaghi, Teresa Mancilla Percino, Mehrdad Pourayoubi and Marco A. Leyva. p-Tolyl bis(o-tolylamido)phosphinate. Acta Cryst. E66, (2010), o1755.

Teresa Mancilla Percino, José Correa-Basurto, José Trujillo-Ferrara, Fernando R. Ramos-Morales, Mario E. Acosta Hernández, Jesus S. Cruz-Sánchez, Margarita Saavedra-Vélez. Molecular Modeling Study of Isoindolines as L-Type Ca2+ Channel blockers by Docking Calculations. Journal Molecular Modeling, 16 (8) 2010, 1377-1382.

Teresa Mancilla Percino, Roxana Magaly Flores Ancona and Marisol López Martínez. New strategy to the synthesis of (N®B) phenyl[N-alkyliminodiacetate-O,O’,N]boranes: The crystal structure of (N®B) phenyl[N-benzyliminodiacetate-O,O’,N]borane, (N®B)phenyl[N-(4-methyl)benzyliminodiace tate-O,O’,N]borane and (N→B) phenyl [N-phenacyliminodiacetate-O,O’,N]borane. Polyhedron, 28 (13) 2009, 2771-2775.

Teresa Mancilla Percino, José Correa Basurto, Karla S. Alavés Carbajal, Nagchielli Valle-Sandoval, and José Trujillo Ferrara. Molecular Modeling study of 2-substituted isoindoline derivatives of a-amino acids as inhibitors of Lipoxygenase by docking simulations. Journal of the Mexican Chemical Society, 53 (1), 2009, 1-6.

Teresa Mancilla Percino, Marisol López Martínez and José Luis León. Diastereoselective synthesis of ß-hydroxyketones. Natural Product Communications, 3 (3), 2008, 329-332.

Teresa Mancilla Percino and Teresita Rocío Cruz Hernández. Synthesis of Methyl-2[N-subtituted-N-(2-hydroxyethyl)]amino-2-hydroxyacetates and 2-hydroxy-4-alkylperhydro-1,4-oxazin-3-onesJournal of the Mexican Chemical Society, 51(4), 2007, 185-192.

Teresa Mancilla, José Correa-Basurto, Karla S. Alavés Carbajal, Evelyn T. J. Sánchez Escalante and José Trujillo Ferrara. Theoretical study of isoindolines to identify them as cyclooxygenase-1 and –2 inhibitors by docking simulations. Journal of the Mexican Chemical Society, 51(2), 2007, 96-102.

Teresa Mancilla, María de los Ángeles Calixto Romo and Lorena Amaya Delgado. Synthesis and characterization of (N®B) phenyl[N-alkyl-N-(2-alkyl)aminodiacetate-O,O´,N]boranes and phenyl[N-alkyl-N-(2-alkyl)aminodiacetate-O,O’,N]boranes. Polyhedron, 26 (4) 2007, 1023-1028.

Teresa Mancilla Percino and David Aaron Nieto Álvarez. Preparation and characterization of Rosmarinecine derivatives. Journal of the Mexican Chemical Society, 50 (4), 2006,169-172.

Teresa Mancilla, Luis S. Zamudio-Rivera, Hiram, I. Beltrán, Rosa Santillan and Norberto Farfán. Synthesis and characterization of new (N→B) phenyl substituted[N-benzyliminodiacetate-O,O’,N]boranes. ARKIVOC, Part (iv), 2005 (6), 366-376. Commemorative Issue in Honor of Prof. Eusebio Juaristi on the occasion of his 55th anniversary. 

David Aaron Nieto-Álvarez, Federico Jiménez-Cruz and Teresa Mancilla. Synthesis and characterization of new di-n-butyl[bis{dimethyl-2-(3-oxo-5-phenyl(4-subtituted)pente-5-ato)malonates}]tin(IV) the crystal structure of di-n-butyl[bis{dimethyl-2-(5-(4-nitrophenyl)-3-oxo-pente-5-ato]malonate}]tin(IV). Polyhedron, 24 (9), 2005, 1054-1062.  

Teresa Mancilla, Luis S. Zamudio-Rivera, Hiram I. Beltrán. Lourdes Carrillo and Norberto Farfán. Synthesis and characterization of new 4-alkyl-2-arylmorpholin-2-ol hydrochlorides. Synthetic Communications, 35 (3), 2005, 357-369.

Patente otorgada

Genaro Rodríguez Uribe; Nicolas Serafín Higuera; José Bonilla Delgado; Cynthia Raquel Trejo Muñoz; Patricio Gariglio Vidal; Teresa Mancilla Percino. Métodos para la prevención de opacidad capsular posterior mediante la inhibición de las vías TGF-ß y WNT/ß-catenina por medio de un inhibidor de HDAC. Título de patente No. 373069. MX/a/2014/002124, (2020).

Síntesis y evaluación biológica de compuestos orgánicos

Las aminas, aminoalcoholes y aminoácidos son compuestos ampliamente utilizados en la síntesis de una gran variedad de compuestos orgánicos polifuncionales con propiedades biológicas interesantes como: anticonvulsivas, amebicidas, antihipertensivas, anxiolíticas, neurolépticas, anticancerígenas, antiinflamatoria, en el tratamiento de enfermedades coronarias y aplicación en síntesis a escala industrial. En este contexto, desarrollamos nuevos métodos para la síntesis de series de nuevos compuestos como las 2-hidroxiacetamidas, ácidos N-alquiliminodiacéticos, 2,6-piperazindionas, isoindolinas, 2-(aminoalquil)acetami-das, 4-alquil-2-arilmorfolinoles, morfolon-3-onas, pirrolizidinas. Caracterización de los compuestos por métodos espectroscópicos y difracción de Rayos-X, así como el análisis estructural de los mismos. Adicionalmente, se ha llevado a cabo la evaluación biológica teórica e in vitro de varios de estos compuestos y muchos de éstos están en lista para su evaluación.

Referencias

Flor Paulina Garrido González, Teresa Mancilla Percino. Synthesis, docking study and inhibitory activity of 2,6- diketopiperazines derived from a-amino acids on HDAC8. Bioorganic Chemistry, 102, 2020, 104080, 1-10.

Juan A. M. De la Rosa, Maricela García-Castañeda, Takuya Nishigaki, Juan Carlos Gómora, Teresa Mancilla-Percino, and Guillermo Ávila. Interaction of MDIMP with the Voltage-Gated Calcium Channels. Molecular Pharmacology, 98 (3), 2020, 211-221.

Genaro Rodríguez-Uribe, Nicolas Serafín-Higuera, Gabriela Damian Morales, Enoc Mariano Cortés-Malagón, Vicky García-Hernández, Odette Verdejo-Torres, Jessica Paulina Campos-Blázquez, Cynthia R. Trejo-Muñoz, Rubén Gerardo Contreras, Rodolfo Ocadiz-Delgado, Carmen Palacios-Reyes, Paul F. Lambert, Anne E. Griep, Teresa Mancilla-Percino, Jaime Escobar-Herrera, Elizabeth Álvarez-Ríos, Carlos Ugarte-Briones, José Moreno, Patricio Gariglio, and José Bonilla-Delgado. HPV16-E6 Oncoprotein Activates TGF-𝛽 and Wnt/𝛽-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model. BioMed Research International, Vol. 2018, Article ID 2847873, 1-17.

Mireille Aline Santamaria-Herrera, Erick Benjamín Ríos-Pérez, Juan Antonio Manuel de la Rosa, Maricela García-Castañeda, Diana Stephanie Osornio-Garduño, Roberto Ramos-Mondragón, Teresa Mancilla-Percino, Guillermo Ávila. MDIMP, a novel cardiac Ca2+ channel blocker with atrial selectivity. European Journal of Pharmacology 2016, 781, 218–228.

Teresa Mancilla-Percino, Cynthia R. Trejo-Muñoz, José Alfredo Díaz-Gandarilla, Patricia Talamás-Rohana, José Eduardo Guzmán Ramírez, Jair Cervantes C. and Armando Figueroa Ortiz. Isoindoline Derivatives of a-Amino Acids as Cyclooxygenase 1 and 2 Inhibitors. Arch. Pharm. Chem. Life Sci., 349 (3), 2016, 175-185.

Cynthia R. Trejo Muñoz, Elvia Mera Jiménez, Rodolfo Pinto-Almazán, José Alfredo Díaz Gandarilla, José Correa-Basurto, José G. Trujillo-Ferrara, Christian Guerra-Araiza, Patricia Talamás Rohana, Teresa Mancilla Percino. Effect of two series of isoindolines over HDAC8 activity and expression. Medicinal Chemical Research, 23, 2014, 3227–3234.

Cynthia R. Trejo Muñoz, Teresa Mancilla Percino, Elvia Mera Jiménez, José Correa-Basurto and José G. Trujillo Ferrara. Partition coefficient determination of a series of isoindolines-2-substituted and its correlation with their antiproliferative activity on HeLa cells. Medicinal Chemical Research, 22 (8), 2013, 4039-4045.

J. Correa-Basurto, F. R. Ramos-Morales, M. H. Matus, M. C. Rosales-Hernández, T.  Mancilla-Percino, J. Trujillo-Ferrara a I. Ilizaliturri-Flores. Docking and DFT Studies to explore the Topoisomerase II ATP Pocket employing 3-Substituted 2,6-Piperazindiones for drug design. Molecular Simulation 38 (13), 2012, 1072-1084.

 

Teresa Mancilla Percino, José Correa-Basurto, José Trujillo-Ferrara, Fernando R. Ramos-Morales, Mario E. Acosta Hernández, Jesús S. Cruz-Sánchez, Margarita Saavedra-Vélez. Molecular Modeling Study of Isoindolines as L-Type Ca2+ Channel blockers by Docking Calculations.  Journal Molecular Modeling, 16 (8), 2010, 1377-1382.

Teresa Mancilla Percino, José Correa Basurto, Karla S. Alavés Carbajal, Nagchielli Valle-Sandoval, and José Trujillo Ferrara. Molecular Modeling study of 2-substituted isoindoline derivatives of a-amino acids as inhibitors of Lipoxygenase by docking simulations. Journal of the Mexican Chemical Society, 53 (1), 2009, 1-6.

Teresa Mancilla Percino, Marisol López Martínez and José Luis León. Diastereoselective synthesis of ß-hydroxyketones. Natural Product Communications, 3 (3), 2008, 329-332.

Teresa Mancilla, José Correa-Basurto, Karla S. Alavés Carbajal, Evelyn T. J. Sánchez Escalante, and José Trujillo Ferrara. Theoretical study of isoindolines to identify them as cyclooxygenase-1 and –2 inhibitors by docking simulations. Journal of the Mexican Chemical Society, 51 (2), 2007, 96-102.

Teresa Mancilla Percino and David Aaron Nieto Álvarez. Preparation and characterization of Rosmarinecine derivatives. Journal of the Mexican Chemical Society, 50 (4), 2006,169-172.

Teresa Mancilla, Luis S. Zamudio-Rivera, Hiram I. Beltrán. Lourdes Carrillo and Norberto Farfán. Synthesis and characterization of new 4-alkyl-2-arylmorpholin-2-ol hydrochlorides. Synthetic Communications, 35 (3), 2005, 357-369.

Teresa Mancilla, Luis S. Zamudio-Rivera, Lourdes Carrillo, Hiram I. Beltrán and Norberto Farfán. Synthesis and characterization of new 2-(alkylamino)acetamides. Arkivoc, Part (xi) “Organic Chemistry in Mexico”, 2003 (11), 2003, 37- 47.

David Aarón Nieto-Álvarez, José Calderón and Teresa Mancilla. Synthesis of (1R,2R,7R,7aS)-1-hydroxymethyl-2,3,5,6,7,7a-hexahydropyrrolizidine-2,7-triol from rosmarinine degradation. Natural Products Research, 17 (1), 2003, 33-36.

Teresa Mancilla, Lourdes Carrillo, Luis S. Zamudio Rivera Hiram I. Beltrán and Norberto Farfán. Synthesis and characterization of piperazine-2,6-diones. Organic Preparations and Procedures International, 34 (1), 2002, 87-94.

Teresa Mancilla, Lourdes Carrillo, Luis S. Zamudio Rivera, Hiram I. Beltrán and Norberto Farfán. Synthesis and characterization of new 2-substituted isoindolines derived of a-aminoacids. Organic Preparations and Procedures International, 33 (4), 2001, 341-349.

Luis S. Zamudio Rivera, Lourdes Carrillo and Teresa Mancilla. Syntheses and characterization of N-alkyl hydroxyacetamides. Organic Preparation and Procedures International, 32 (1), 2000, 84-88.

Luis S. Zamudio Rivera, Lourdes Carrillo and Teresa Mancilla. Syntheses and characterization of 2-Hydroxy-N-(2’-hydroxyalkyl)acetamides. Heteroatom Chem., 10 (2), 1999, 153-158.

Teresa Mancilla, Ma. de Jesús Rosales, Efrén V. García-Báez and Lourdes Carrillo. Syntheses and characterization of new (2S)-2-hydroxy-1,4-oxazin-3-ones derived from b-aminoalcohols. Heteroatom Chem., 6 (6), 1995, 605-609.

 

Compuestos orgánicos de estaño

Desde 1965 los compuestos de estaño llamaron la atención debido a la gran variedad de aplicaciones prácticas e industriales y más tarde como agentes antitumorales.
Nuestro interés en la síntesis de nuevos compuestos orgánicos de estaño desde el punto de vista de análisis estructural, así como posibles agentes antitumorales, preparamos principalmente compuestos diorganoestaño (IV) derivados de compuestos orgánicos polifuncionales.

Referencias

David Aarón Nieto-Álvarez, Federico Jiménez-Cruz and Teresa Mancilla. Synthesis and characterization of new di-n-butyl[bis{dimethyl-2-(3-oxo-5-phenyl(4-subtituted)pente-5-ato)malonates}]tin(IV) the crystal structure of di-n-butyl[bis{dimethyl-2-(5-(4-nitro-phenyl)-3-oxopente-5-ato]malonate}]tin(IV). Polyhedron, 24 (9), 2005, 1054-1062.  

Norberto Farfán, Teresa Mancilla, Rosa Santillán, Atilano Gutiérrez, Luis S. Zamudio-Rivera, Hiram I. Beltrán. Preference of di-n-butyltinIV compounds to build O….Sn bonds in fused ring with five-six members. J. Organomet. Chem. 689 (22), 2004, 3481-3491.

Hiram I. Beltrán, Luis S. Zamudio-Rivera, Teresa Mancilla, Rosa Santillán and Norberto Farfán. One-Step Preparation, Structural Assignment, and X-ray Study of 2,2-di-n-butyl- and 2,2-diphenyl-6-aza-1,3-dioxa-2-stannabenzo- cyclononen-4-ones. Chem. Eur. J. 9, 2003, pp. 2291-2306.

David Aarón Nieto-Alvárez, Federico Jiménez-Cruz and Teresa Mancilla. Synthesis and characterization of new di-n-butylhydroxytin(IV) derived compounds from 1,3-diketone malonates. Polyhedron, 21, 2002, 417-420.

Teresa Mancilla, Lourdes Carrillo, Luis S. Zamudio Rivera, Carlos Camacho Camacho, Dick de Vos, Robert Kiss, Francis Darro, Bernard Maahieu, Edward R. Tiekink, Hubert Rahier, Marcel Gielen, Martine Kemmer, Monique Biesemans and Rudolph Willem. Di-n-butyltin(IV) derivatives of bis(carboximethyl)benzylamines: Synthesis, structure and X-ray structure characterization and in vitro antitumour properties. Applied Organomet. Chem., 15, 2001, 593-603.

Teresa Mancilla, Dolores Castillo, Lourdes Carrillo and Norberto Farfán. Diorganotin (IV) compounds derived from N-methyl-2,2’-diphenolamine and 2,2’-diphenolamine. Heteroatom Chem., 10 (2), 1999, 133-139.

Teresa Mancilla and Lourdes Carrillo. Synthesis and characterization of diorganotin (IV) compounds derived from optically active N-methyl-N(1-methyl-2-phenyl-2-hydroxyethyl)glycines. Main Group Met. Chem., 17 (5), 1994, 363-375.

Teresa Mancilla, Lourdes Carrillo and Apolinar Cerezo. Triphenyltin and diphenyltin compounds derived from ethanolamines. Trends in Organometallic Chemistry 1, 1994, 163-166. ED.  Research Trends ISSN: 0972-4354.

Larry R. Sherman, Ginny Lee Kellner and Teresa Mancilla. The acute oral toxicity of di-tert-butyltin-2,6-pyridine dicarboxilate. Main Group Met. Chem., 13, (1), 1990, 51-53.

Teresa Mancilla, Norberto Farfán, Dolores Castillo, Lydia Molinero, Abdelkader Meriem, Rudolph Willem, Bernard Mahieu and Marcel Gielen. Synthesis and characterization of a series of diorganotin (IV) compounds of the type R2Sn (O-C6H4-o-NH-CpCp-NH-C6H4-o-O). Main Group Met. Chem., 12, (3-4), 1989, 213-223.

Marcel Gielen, Eddie Joosen, Teresa Mancilla, Klaus Jurkschat, Rudolph Willem, Cornelis Roobol y Jan Bernheim. Synthesis and in vitro antineoplastic activity of diorganostannylene Derivatives of 2,6-pyridine dicarboxilic acid. Platinum and other metal coordination compounds in cancer chemotherapy. Vol 54 (1988) Ed. Marine Nicoloni, Martinus Nijhoff Publishing, (Padua, Italia), (1987), 662-665. ISBN: 978-1-4613-1717-3.

Marcel Gielen, Eddie Joosen, Teresa Mancilla, Klaus Jurkschat, Rudolph Willem, Cornelis Roobol, Jan Bernheim, Ghanem Atassi, Friedo Huber, Eckehard Hoffman, Hans Preut and Bernard Mahieu. Diorganostannylene derivatives of 2,6-pyridine dicarboxilic acid: synthesis, spectroscopic characterization, X-ray structure analysis, in vitro and in vivo anti-tumour activity. Main Group Met. Chem., 10, (3) 1987, 147-167.

Marcel Gielen, Teresa Mancilla, Johan Ramharter and Rudolph Willem Synthesis and characterization of ethylphenylstannylene derivatives of ethylene glycol, cytidine and 3,5-diiodosalicyclic acid. J. Organomet. Chem., 328, 1987, 61-70.

Marcel Gielen, Rudolph Willem, Teresa Mancilla, Johan Ramharter and Eddie Joosen Strategy for the development of novel organotin anti-cancer agents. Rev. Si, Ge, Sn, Pb cpds, 9, (4), 1986, 349-365.

Heterociclos de boro y sus aplicaciones

Nuestro interés en la síntesis de ácidos iminodiacéticos y sus derivados se debe a que son buenos ligantes para la síntesis de nuevos compuestos orgánicos de estaño como posibles agentes antitumorales, sin embargo, los métodos descritos en la literatura son escasos y solo algunos están disponibles comercialmente. En el laboratorio desarrollamos nuevos métodos para la síntesis de nuevos ácidos N-alquiliminodiacéticos y N,2-dialquilaminodiacéticos a partir del (N→B) fenil[iminodiacetato-O,O’,N]borano y de los (N→B) fenil[N- alquiliminodiacetato-O,O’,N]borano.

 

REFERENCIAS

Teresa Mancilla Percino, José Eduardo Guzmán Ramírez, Elvia Mera Jiménez and Cynthia Raquel Trejo Muñoz. Synthesis, characterization of novel isoindolinyl- and bis-isoindolinylphenyl boronic anhydrides. Antiproliferative activity on glioblastoma cells and microglial cells assays of boron and isoindolines compounds. Journal of Organometallic Chemistry 891, 2019, 35-43.

Teresa Mancilla Percino, Roxana Magaly Flores Ancona and Marisol López Martínez. New strategy to the synthesis of (N→B) phenyl[N-alkyliminodiacetate-O,O’,N]boranes: The crystal structure of (N®B) phenyl[N-benzyliminodiacetate-O,O’,N]borane, (N→B)phenyl[N-(4-methyl) benzyliminodia cetate- O,O’,N]borane and (N→B) phenyl [N-phenacyliminodiacetate-O,O’,N]borane. Polyhedron, 28 (13), 2009, 2771-2775.

Teresa Mancilla, María de los Ángeles Calixto Romo and Lorena Amaya Delgado. Synthesis and characterization of (N→B) phenyl[N-alkyl-N-(2-alkyl)aminodiacetate-O,O´,N]boranes and phenyl[N-alkyl-N-(2-alkyl)aminodiacetate-O,O’,N]boranes. Polyhedron, 26 (4), 2007, 1023-1028.

Teresa Mancilla, Luis S. Zamudio-Rivera, Hiram, I. Beltrán, Rosa Santillán and Norberto Farfán. Synthesis and characterization of new (N→B) phenyl substituted[N-benzyl-iminodiacetate-O,O’,N]boranes. ARKIVOC, Part (iv), 2005 (6), 366-376. Commemorative Issue in Honor of Prof. Eusebio Juaristi on the occasion of his 55th anniversary.

Hiram I. Beltran, Luis S. Zamudio-Rivera, Teresa Mancilla, Rosa Santillán, Norberto Farfán. X-ray Analysis and structural characterization of 2-phenyl-6-aza-1,3-dioxa-2-borabenzo cyclononenones. J. Organomet. Chem. 657 (1-2), 2002, 194-204.

Teresa Mancilla, Herbert Höpfl, Guadalupe Bravo and Lourdes Carrillo. Crystal and molecular structure of (N→B)phenyl[N-methylimino-diacetate-O,O’,N]borane. Main Group Met. Chem., 20 (1), 1997, 31-36.

Teresa Mancilla, Lourdes Carrillo and Ma. de la Paz Reducindo. Syntheses of (N→B)phenyl[alkylaminodiacetate-O,O’,N]borane. Polyhedron, 15 (21), 1996, 3777-3785.

Teresa Mancilla, Lourdes Alarcón and Lourdes Carrillo. Syntheses and characterization of (NB) phenyl[arylaminodiacetate-O,O’,N]borane and N-arylaminodiacetic acids. Heteroatom Chem., 5 (5/6), 1994, 455-462.

Teresa Mancilla and Sandra L. Galvez. a-And N-alkylation of boron heterocycles derived from iminodiacetic acids. Main Group Met. Chem., 15 (1), 1992, 9-17.

Norberto Farfán, Teresa Mancilla, Dolores Castillo, Guillermo Uribe, Lourdes Carrillo, Pedro Joseph-Nathan and Rosalinda Contreras. Nmr and X-ray difracction studies of two bicyclic borates containing chiral boron and nitrogen atoms. J. Organomet. Chem., 381, 1990, 1-13.

Teresa Mancilla and Rosalinda Contreras. Asymmetric synthesis of new bicyclic phenylboronic esters containing configurationally stable chiral nitrogen and boron. J. Organomet. Chem., 321, (2), 1987, 191-198.

Teresa Mancilla, Rosalinda Contreras and Bernd Wrackmeyer. New bicyclic organylboronic esters derived from iminodiacetic acids. J. Organomet. Chem., 307, 1986, 1-6.